Association between CD200 molecule expression on B lymphocytes and levels of specific IgE against molecular components of storage mites, animals and molds in atopic dermatitis patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10503580" target="_blank" >RIV/00179906:_____/25:10503580 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/25:10503580

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R8ThcFK1Ua" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R8ThcFK1Ua</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1547691X.2025.2561586" target="_blank" >10.1080/1547691X.2025.2561586</a>

Result language

angličtina

Original language name

Association between CD200 molecule expression on B lymphocytes and levels of specific IgE against molecular components of storage mites, animals and molds in atopic dermatitis patients

Original language description

This study investigated the relationship between CD200 molecule expression on B- lymphocytes and the levels of specific IgE to molecular components of storage mites (Gly d 2, Lep d 2), dog (Can f 1, Can f 2), cat (Fel d 1), shrimp (Pen m 2), molds (Asp f 6, Mala s 11, Alt a 6, Alt a 1, Mala s 6, Cla h), and German cockroach (Bla g 9) in patients with atopic dermatitis (AD), both with and without dupilumab therapy. The study included 46 patients with AD− 26 without dupilumab treatment and 20 with dupilumab treatment. Serum levels of specific IgE were measured using the ALEX2 Allergy Xplorer diagnostic microarray and CD200 molecule was evaluated with the use of flow cytometry. Spearman’s rank correlation coefficient was used to assess the relationship between B-lymphocyte CD200 expression and specific IgE levels to molecular components. According to the results, the association between CD200 expression and specific IgE levels to molecular components was low (up to 10%) in AD patients without dupilumab therapy. In patients with dupilumab therapy, the association was non-linear, indicating that the two monitored parameters had opposite effects. In conclusion, the present study did not confirm any association between the CD200 molecule on B-lymphocytes and specific IgE levels to molecular components.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30216 - Dermatology and venereal diseases

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Immunotoxicology

ISSN

1547-691X

e-ISSN

1547-6901

Volume of the periodical

22

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

2561586

UT code for WoS article

001585133000001

EID of the result in the Scopus database

2-s2.0-105017669063