A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10503845" target="_blank" >RIV/00179906:_____/25:10503845 - isvavai.cz</a>

Alternative codes found

RIV/00669806:_____/25:10503845

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3icGffDils" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=3icGffDils</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-14893-1" target="_blank" >10.1038/s41598-025-14893-1</a>

Result language

angličtina

Original language name

A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism

Original language description

Pulmonary embolism (PE) can result in long-term sequelae, such as post-PE syndrome, including persistent dyspnea and chronic thromboembolic pulmonary hypertension (CTEPH). Existing prediction tools for severe post-PE complications lack sensitivity and specificity. This study aimed to develop a machine learning model to identify patients at risk for long-term consequences after PE. Using data from the RIETE registry, the largest prospective international PE registry, we developed supervised machine learning models to identify patients at increased risk of CTEPH and post-PE syndrome. Our approach involved data preprocessing, model training via random forest algorithm, and validation through Monte-Carlo cross-validation. The performance of the CTEPH prediction model was benchmarked against an existing score. Of the 57,981 PE patients in the RIETE registry, 5,217 were eligible for inclusion. Median age was 68 years, with 50.6% men. Machine learning was based on 111 predictor variables, with 171 patients (3.3%) developing CTEPH. The CTEPH model demonstrated good performance with an AUC of 0.74 (95%CI: 0.73-0.75), significantly outperforming the existing CTEPH prediction score (0.57; 0.54-0.61). Additionally, 1,310 (25.1%) patients were defined as having post-PE syndrome six months after index PE. The post-PE syndrome model showed poorer performance with an AUC of 0.62 (0.61-0.62). Key predictor variables across both models included chest pain at presentation, PE location, troponin, side of clot, and dyspnea at presentation. Machine learning models show promise in predicting CTEPH but are less effective for post-PE syndrome. Future refinement, including integrating imaging data, is necessary to improve predictive performance and clinical utility.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Scientific Reports

ISSN

2045-2322

e-ISSN

2045-2322

Volume of the periodical

15

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

32744

UT code for WoS article

001580597500022

EID of the result in the Scopus database

2-s2.0-105016908262