Perioperative leukocyte-plateletcrit shift as a prognostic signature in glioblastoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10504840" target="_blank" >RIV/00179906:_____/25:10504840 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/25:10504840
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ctruQvlM7n" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ctruQvlM7n</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11060-025-05302-8" target="_blank" >10.1007/s11060-025-05302-8</a>
Alternative languages
Result language
angličtina
Original language name
Perioperative leukocyte-plateletcrit shift as a prognostic signature in glioblastoma
Original language description
Purpose Circulating inflammatory indices derived from routine blood counts may offer pragmatic prognostic information in glioblastoma (GB), yet the prognostic role of plateletcrit (PCT) and of peri-treatment dynamics in leukocyte-platelet coupling remains underexplored. Methods We retrospectively studied 95 adults with histologically confirmed GB (48 men, 47 women; median age 64.5 years) treated adjuvantly with radiotherapy and chemotherapy with complete blood counts obtained at four windows: pre-operative, post-operative, pre-adjuvant, and post-adjuvant. From leukocytes, platelets (PLT), plateletcrit (PCT), and mean platelet volume (MPV) we derived all within-timepoint ratios and inter-timepoint differences (Delta). Overall survival (OS) in days was modeled using Cox proportional hazards (per + 1 SD), with Benjamini-Hochberg false-discovery summaries; a multivariable model adjusted for age, sex, extent of resection, radiotherapy, concomitant temozolomide (TMZ), and number of adjuvant TMZ cycles was calculated. Results Median overall survival (OS) was 406 days, with 80 deaths. In univariate models, dynamic indices predominated: the post-operative rise in leukocytes relative to plateletcrit (Delta post-op - pre-op leu/PCT) showed the strongest adverse association (HR 1.60, 95% CI 1.22-2.10; p = 0.0007; BH-FDR q = 0.09), with concordant signals for Delta leu/PLT (HR 1.43, 95% CI 1.14-1.79; p = 0.002) and a protective inverse for Delta PCT/leu (HR 0.66, 95% CI 0.50-0.87; p = 0.003). Cross-sectionally, higher post-operative leu/PCT and leu/PLT and higher post-adjuvant leukocytes and leu/MPV were adverse (all p < 0.05). In the multivariable model adjusting for age, sex, extent of resection, radiotherapy, concomitant temozolomide (TMZ), and number of adjuvant TMZ cycles, Delta leu/PCT remained independently associated with worse OS (HR 1.62, 95% CI 1.04-2.52; p = 0.031), while concomitant TMZ (HR 0.18, 95% CI 0.05-0.68; p = 0.012) and greater adjuvant TMZ exposure (per + 1 SD; HR 0.48, 95% CI 0.29-0.78; p = 0.003) were protective. Conclusions Dynamic leukocyte-platelet coupling-especially Delta (post-op - pre-op) leu/PCT-provides independent prognostic information beyond standard covariates. CBC-based trajectories are low-cost and scalable and warrant prospective validation. Interpretation is limited by the absence of systematic MGMT methylation data and requires external validation and comparison with other prognostic scoring systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuro-Oncology
ISSN
0167-594X
e-ISSN
1573-7373
Volume of the periodical
176
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
27
UT code for WoS article
001597462100005
EID of the result in the Scopus database
2-s2.0-105019329567