Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10507709" target="_blank" >RIV/00179906:_____/25:10507709 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43929270 RIV/00216208:11150/25:10507709
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1eiqPSlxH1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=1eiqPSlxH1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0954422425100292" target="_blank" >10.1017/S0954422425100292</a>
Alternative languages
Result language
angličtina
Original language name
Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation
Original language description
The increasing focus on longevity and cellular health has brought into the spotlight two key compounds, urolithin A (UroA) and spermidine, for their promising roles in autophagy and mitophagy. Urolithin A, a natural metabolite derived from ellagitannins, stimulates mitophagy through pathways such as PTEN induced kinase 1 (PINK1)/Parkin RBR E3 ubiquitin protein ligase (PRKN), leading to improved mitochondrial health and enhanced muscle function. However, spermidine, a polyamine found in various food sources, induces autophagy by regulating key signaling pathways such as 5 ' AMP-activated protein kinase (AMPK) and sirtuin 1, thus mitigating age-related cellular decline and promoting cardiovascular and cognitive health. While both UroA and spermidine target cellular maintenance, they affect overlapping as well as distinct signalling pathways. Thus, they do not have completely identical effects, although they overlap in many ways, and offer varying benefits in terms of metabolic function, oxidative stress reduction and longevity. This review article aims to describe the mechanisms of action of UroA and spermidine not only on the maintenance of cellular health, which is mediated by the induction and maintenance of autophagy and mitophagy, but also on their potential clinical relevance. The analysis presented here suggests that although both compounds are safe and offer substantial health benefits and are involved in both autophagy and mitophagy, the role of UroA in mitophagy places it as a targeted intervention for mitochondrial health, whereas the broader influence of spermidine on autophagy and metabolic regulation may provide more comprehensive anti-ageing effects.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30304 - Public and environmental health
Result continuities
Project
<a href="/en/project/EH23_021%2F0008439" target="_blank" >EH23_021/0008439: Biomedical Indicators for Personalized Medicine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nutrition Research Reviews
ISSN
0954-4224
e-ISSN
1475-2700
Volume of the periodical
39
Issue of the periodical within the volume
December
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
e8
UT code for WoS article
001652157900001
EID of the result in the Scopus database
2-s2.0-105026082088