Prognostic utility of biomarkers in predicting of one-year outcomes in patients with aortic stenosis treated

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F12%3A%230000247" target="_blank" >RIV/00209775:_____/12:#0000247 - isvavai.cz</a>

Result on the web

<a href="http://plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048851" target="_blank" >http://plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048851</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0048851" target="_blank" >10.1371/journal.pone.0048851</a>

Result language

angličtina

Original language name

Prognostic utility of biomarkers in predicting of one-year outcomes in patients with aortic stenosis treated

Original language description

The aim of the work was to find biomarkers identifying patients at high risk of adverse clinical outcomes after TAVI and SAVR in addition to currently used predictive model (EuroSCORE). There is limited data about the role of biomarkers in predicting prognosis, especially when TAVI is available. The multi-biomarker sub-study included 42 consecutive high-risk patients allocated to TAVI tranfemoral and transapical (n=29), or SAVR (n=13). Standardized endpoints were prospectively followed during the 12-month follow-up. The clinical outcomes after both TAVI and SAVR were comparable. Malondialdehyde served as the best predictor of a combined endpoint at 1 year with AUC (ROC analysis) = 0.872 for TAVI group, resp. 0.765 (p<0.05) for both TAVI and SAVR groups. Increased levels of MDA, matrix metalloproteinase 2, tissue inhibitor of metalloproteinase (TIMP1), ferritin-reducing ability of plasma, homocysteine, cysteine and 8-hydroxy-2-deoxyguanosine were all predictors of the occurrence of comb

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Plos One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000312386800004

EID of the result in the Scopus database

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