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X-linked agammaglobulinemia in community-acquired pneumonia cases reveaeled by immunoglobulin level screening at hospital admission

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F13%3A%230000275" target="_blank" >RIV/00209775:_____/13:#0000275 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1055/s-0033-1354415" target="_blank" >http://dx.doi.org/10.1055/s-0033-1354415</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1055/s-0033-1354415" target="_blank" >10.1055/s-0033-1354415</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    X-linked agammaglobulinemia in community-acquired pneumonia cases reveaeled by immunoglobulin level screening at hospital admission

  • Original language description

    In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare,some of the infections seen in immunodeficient patients are common. Defective antibody production represents the largest group among these disorders, with otitis, sinusitis and pneumonia as the most frequent initial manifestation. We performed a prospective study of humoralimmunity in children hospitalized due to community-acquired pneumonia in tertiary care hospital. Out of 254 patients (131 boys, 123 girls, median age 4.5 years) recruited over 3 years, we found 2 boys (age 11 and 21 months) lacking serum immunoglobulinsand circulating B cells. Subsequent genetic analysis confirmed diagnosis of X-linked agammaglobulinemia. Despite their immunodeficiency, the pneumonia was uncomplicated in both patients and did not call for immunological evaluation. Howev

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FN - Epidemiology, infection diseases and clinical immunology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS10398" target="_blank" >NS10398: Significance of TACI mutations and lymphocyte subpopulations in pathogenesis of selective IgA deficiency</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Klinische Pädiatrie

  • ISSN

    0300-8630

  • e-ISSN

  • Volume of the periodical

    225

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    4

  • Pages from-to

    339-342

  • UT code for WoS article

  • EID of the result in the Scopus database