Adjuvant cardioprotection in cardiac surgery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F14%3A%230000303" target="_blank" >RIV/00209775:_____/14:#0000303 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/bmri/2014/808096/" target="_blank" >http://www.hindawi.com/journals/bmri/2014/808096/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/808096" target="_blank" >10.1155/2014/808096</a>

Result language
angličtina
Original language name
Adjuvant cardioprotection in cardiac surgery
Original language description
Cardiac surgery patients are now more risky in terms of age, comorbidities, and the need for complex procedures. It brings about reperfusion injury, which leads to dysfunction and/or loss of part of the myocardium. These groups of patients have a higherincidence of postoperative complications and mortality. One way of augmenting intraoperative myocardial protection is the phenomenon of myocardial conditioning, elicited with brief nonlethal episodes of ischemia-reperfusion. In addition, drugs are beingtested that mimic ischaemic conditioning. Such cardioprotective techniques are mainly focused on reperfusion injury, a complex response of the organism to the restoration of coronary blood flow in ischaemic tissue, which can lead to cell death. Extensiveresearch over the last three decades has revealed the basic mechanisms of reperfusion injury and myocardial conditioning, suggesting its therapeutic potential. But despite the enormous efforts that have been expended in preclinical studi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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