Association between the timing of surgery for complicated, left-sided infective endocarditis and survival

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F19%3AN0000032" target="_blank" >RIV/00209775:_____/19:N0000032 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/19:00109677

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0002870319300055" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0002870319300055</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ahj.2019.01.004" target="_blank" >10.1016/j.ahj.2019.01.004</a>

Result language

angličtina

Original language name

Association between the timing of surgery for complicated, left-sided infective endocarditis and survival

Original language description

Background: In patients with active infective endocarditis (IE), the relationship between timing of surgery and survival is uncertain. The objective was to evaluate clinical characteristics associated with timing of surgery and the association between surgical timing and 6-month survival in complicated, left-sided IE. Methods: In a prospective, multicenter, observational registry (The International Collaboration on Endocarditis-PLUS, registry from 2008 to 2012), clinical factors associated with timing of surgery during the index hospitalization were determined among 485 adult patients with definite, complicated, left-sided IE who underwent cardiac surgery during their index hospitalization. The relationship between early surgical intervention (<7 days from admission to surgery center) and outcome after surgery was analyzed. The primary end point of the study was 6-month survival. Results: The median time to surgery from admission to surgical center was 7 (interquartile range 2-15) days. Patients who underwent earlier surgery were more likely transferred to the surgical center (74.2% vs 46.4%, P < .001) and had a lower percentage of preexisting heart failure (before IE diagnosis) (6.0% vs 17.3%, P < .001) but higher rate of acute heart failure (53.2% vs 38.4%, P = .001). Variables independently associated with surgery <7 days from admission were patient transfer, acute heart failure, and nonelective surgical status (C-index = 0.84), but predicted operative risk was not. Cox proportional hazards modeling with inverse probability of treatment weighting found that earlier surgery was associated with a trend toward higher 6-month mortality compared with later surgery (hazard ratio = 1.68, 95% CI 0.97-2.96; P = .065), particularly surgery within 2 days of admission or transfer. Mortality was significantly associated with operative risk and complicated IE, including Staphylococcus aureus infection and presence of abscess. Conclusions: Earlier surgery in IE is strongly associated with acute heart failure and surgical urgency. After adjustment for operative risk and IE complications, earlier surgery <7 days from admission was associated with a trend toward higher 6-month overall mortality compared with surgery later in the index hospitalization.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Heart Journal

ISSN

0002-8703

e-ISSN

—

Volume of the periodical

210

Issue of the periodical within the volume

April 2019

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

108-116

UT code for WoS article

000462587600013

EID of the result in the Scopus database

2-s2.0-85061773830