PLAUR splicing pattern in hereditary angioedema patients’ monocytes and macrophages.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F23%3AN0000002" target="_blank" >RIV/00209775:_____/23:N0000002 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s11033-023-08391-8" target="_blank" >https://link.springer.com/article/10.1007/s11033-023-08391-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11033-023-08391-8" target="_blank" >10.1007/s11033-023-08391-8</a>

Result language
angličtina
Original language name
PLAUR splicing pattern in hereditary angioedema patients’ monocytes and macrophages.
Original language description
The PLAUR gene encodes the urokinase-like plasminogen activator receptor (uPAR) and may undergo alternative splicing. Excluding cassette exons 3, 5 and 6 from the transcript results in truncated protein variants whose precise functions have not been elucidated yet. The PLAUR gene is one of several expressed in myeloid cells, where uPAR participates in different cellular processes, including the contact activation system and kallikrein-kinin system, which play an important role in hereditary angioedema (HAE) pathogenesis. A hypothesis about the PLAUR splicing pattern impact on HAE severity was tested.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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