The effects of RARa and RARa proteins on growth, viability, and differentiation of v-myb-transformed monoblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F00%3A00000107" target="_blank" >RIV/00209805:_____/00:00000107 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The effects of RARa and RARa proteins on growth, viability, and differentiation of v-myb-transformed monoblasts

Original language description

We studied differentiation, proliferation, and death process in the cell line of v-myb-transformed monoblasts BM2 and their retinoic acid receptor (RAR) a- and retinoid X receptor (RXR) a-expressing derivatives after axposure to four different retinoids:all-trans retinoic acid, 9-cis retinoic acid, TTNPB, and LG1000153. The effects of retinoids on the phenotype of BM2, BM2RAR, and BM2RXR cells were correlated with the transcription activation function of the v-Myb oncoprotein of avian myeloblastosis virus. Our results suggest that ligand-activated RARa protein is primarily engaged in control of proliferation and differentiation of v-myb-transformed monoblasts, while activated RXRa protein controls their differentiation and death.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood Cells, Molecules, and Diseases

ISSN

1079-9796

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

neuv.

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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