Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000407" target="_blank" >RIV/00209805:_____/13:#0000407 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0304383513000773" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0304383513000773</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.canlet.2013.01.034" target="_blank" >10.1016/j.canlet.2013.01.034</a>
Alternative languages
Result language
angličtina
Original language name
Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2
Original language description
The pro-metasta tic protein anterior gradient- 2 (AGR2) was previously demonstrated as a predictive factor of poor response to tamoxifen treatment . In this study we aimed to delineate the key signalling pathway that may contribute to regulation of AGR2protein induction in order to identify novel targets to overcome tamoxifen resistance in tumour cells. Together, our data identify PDPK1-AKT as a pro-oncogenic signalling pathway that triggers AGR2 protein induction in response to tamoxifen and suggest that AKT inhibitors could be used as part of a therapeutic strategy to treat tamoxifen resistant, AGR2 overexpressing cancers.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Letters
ISSN
0304-3835
e-ISSN
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Volume of the periodical
333
Issue of the periodical within the volume
27
Country of publishing house
IE - IRELAND
Number of pages
7
Pages from-to
187-193
UT code for WoS article
000318838700007
EID of the result in the Scopus database
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