p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000432" target="_blank" >RIV/00209805:_____/13:#0000432 - isvavai.cz</a>
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859419/pdf/JCI70355.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859419/pdf/JCI70355.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1172/JCI70355" target="_blank" >10.1172/JCI70355</a>
Alternative languages
Result language
angličtina
Original language name
p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
Original language description
Cellular senescence contributes to aging and decline in tissue function. p53 isoform switching regulates replicative senescence in cultured fibroblasts and is associated with tumor progression. Here, we found that the endogenous p53 isoforms ?133p53 andp53? are physiological regulators of proliferation and senescence in human T lymphocytes in vivo. Peripheral blood CD8+ T lymphocytes collected from healthy donors displayed an age-dependent accumulation of senescent cells (CD28?CD57+) with decreased ?133p53 and increased p53? expression. Human lung tumor-associated CD8+ T lymphocytes also harbored senescent cells. Cultured CD8+ blood T lymphocytes underwent replicative senescence that was associated with loss of CD28 and ?133p53 protein. In poorly proliferative, ?133p53-low CD8+CD28? cells, reconstituted expression of either ?133p53 or CD28 upregulated endogenous expression of each other, which restored cell proliferation, extended replicative lifespan and rescued senescence phenotypes
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Clinical Investigation
ISSN
0021-9738
e-ISSN
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Volume of the periodical
123
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
5247-5257
UT code for WoS article
000327826100029
EID of the result in the Scopus database
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