Chaperones and evolution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F13%3A%230000447" target="_blank" >RIV/00209805:_____/13:#0000447 - isvavai.cz</a>
Result on the web
<a href="http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-10.pdf" target="_blank" >http://www.mzm.cz/fileadmin/user_upload/publikace/casopisy/fm_49_2_2013/fm-2-2013-abstract-10.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Chaperones and evolution
Original language description
Phenotypic robustness is enabled by several mechanisms masking detrimental genetic variations in individuals. These mechanisms involve gene duplication and functional redundancy of cellular pathways. Recently the role of Hsp90 chaperone system was suggested in the process of buffering genetic variation on the protein level. This activity of chaperones has a profound effect on the accumulation of large numbers of phenotypically silent genotypes and thus may play an important role in evolution.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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