High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A%230000502" target="_blank" >RIV/00209805:_____/14:#0000502 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/jop.12074/abstract;jsessionid=4DB5A62D7481121DF746467FE256842E.f04t03" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jop.12074/abstract;jsessionid=4DB5A62D7481121DF746467FE256842E.f04t03</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jop.12074" target="_blank" >10.1111/jop.12074</a>

Result language
angličtina
Original language name
High expression of p63 is correlated to poor prognosis in squamous cell carcinoma of the tongue
Original language description
p63 proteins are important in formation of the oral mucosa. Normal oral mucosa shows a balance between the six protein isoforms, whereas an imbalance between them is seen in squamous cell carcinomas (SCC). There is controversy over the clinical impact ofp63 in SCC, which may relate to different expression in different areas. In addition, p63 isoforms can act as p53-like molecules (TAp63) or can inhibit p53 functions (delNp63) and expression of these isoforms varies in different tumours. Here, we choseto concentrate on the most common intra-oral sub-site, SCC of the mobile tongue. Total p63, delNp63 and TAp63 were analysed separately using immunohistochemistry. The percentage of cells and intensity of expression of different isoforms of p63 was evaluated using a quick score method and correlated with clinical data in a group of 87 patients with tongue SCC. All tumours expressed p63 in at least 60% of the cells when using two different antibodies detecting all 6 isoforms. p63 expressio
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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