Titanocene dihalides and ferrocenes bearing a pendant ?-D-Xylofuranos-5-yl or ?-D-Ribofuranos-5-yl Moiety. Synthesis, characterization, and cytotoxic activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A%230000516" target="_blank" >RIV/00209805:_____/14:#0000516 - isvavai.cz</a>
Result on the web
<a href="http://pubs.acs.org/doi/abs/10.1021/om500200r" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/om500200r</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/om500200r" target="_blank" >10.1021/om500200r</a>

Result language
angličtina
Original language name
Titanocene dihalides and ferrocenes bearing a pendant ?-D-Xylofuranos-5-yl or ?-D-Ribofuranos-5-yl Moiety. Synthesis, characterization, and cytotoxic activity
Original language description
Titanocene dichlorides of general formula [(?5-C5H5)(?5-C5H4R)TiCl2] (where R = 5-deoxy-1,2-di-O-isopropylidene-3-O-benzyl-?-D-xylofuranos-5-yl (Xylf) (8a); R = 5-deoxy-1,2-di-O-isopropylidene-3-O-benzyl-?-D-ribofuranos-5-yl (Ribf) (8b)) and [(?5-C5H4R)2TiCl2] (R = Xylf (9a); R = Ribf (9b)) were prepared by reaction of the corresponding lithium cyclopentadienides 7a,b with an equimolar amount of [(?5-C5H5)TiCl3] or a 0.5 mol amount of [TiCl4(THF)2]. Titanocene difluorides of the general formula [(?5-C5H4R1)(?5-C5H4R2)TiF2] (R1 = H and R2 = Ribf (10); R1 = R2 = Xylf (11a); R1 = R2 = Ribf (11b)) were obtained by fluorination of the corresponding titanocene dichlorides 8b and 9 with the fluorinating agent {2-(CH2NMe2)C6H4-?C,N}(n-Bu)2SnF in high yields. Alternatively, complexes 11 were prepared in a straightforward way by direct reaction of [TiF4(THF)2] with 2 equiv of the corresponding lithium cyclopentadienide 7a,b. Ferrocene complexes [(?5-C5H4R)2Fe] (R = Xylf (12a); R = Ribf (12b)) we
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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