Significant anti-tumor effectiveness of imatinib in C-kit negative gastrointestinal stromal tumor - case report

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F14%3A%230000587" target="_blank" >RIV/00209805:_____/14:#0000587 - isvavai.cz</a>
Result on the web
<a href="http://www.linkos.cz/files/klinicka-onkologie/183/4392.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/183/4392.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Significant anti-tumor effectiveness of imatinib in C-kit negative gastrointestinal stromal tumor - case report
Original language description
Inoperable c-kit negative gastrointestinal stromal tumor (GIST) is commonly considered to be highly resistant to systemic therapy. We present a case of a woman with an abdominal sarcoma-like tumor diagnosed at the age of 26. The patient underwent severalsurgical procedures and courses of cytostatic therapy without any substantial effect. Later, the tumor was reclassified as c-kit negative GIST harbouring the mutation in exon 12 of PDGFRA gene. Hence, the therapy with imatinib mesylate was initiated, resulting in partial remission of metastatic lesions and further stabilization of the disease for five yeas to date. We therefore consider imatinib mesylate an appropriate therapy for c-kit negative GIST bearing PDGFRA mutations.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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