The presence of B-cell activating factor (BAFF) in umbilicalcord blood in both healthy and pre-eclamptic pregnanciesand in human breast milk

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000624" target="_blank" >RIV/00209805:_____/15:#0000624 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/15:00082636 RIV/65269705:_____/15:00063666
Result on the web
<a href="http://dx.doi.org/10.1016/j.jri.2014.12.003" target="_blank" >http://dx.doi.org/10.1016/j.jri.2014.12.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jri.2014.12.003" target="_blank" >10.1016/j.jri.2014.12.003</a>

Result language
angličtina
Original language name
The presence of B-cell activating factor (BAFF) in umbilicalcord blood in both healthy and pre-eclamptic pregnanciesand in human breast milk
Original language description
B-cell activating factor (BAFF) is an important immune regulator that was recently reported to be secreted by placenta. The aim of the study was to investigate the presence of BAFF in umbilical cord blood, maternal serum, and breast milk in normal and in pre-eclamptic pregnancies. Pairs of maternal serum/umbilical cord blood were obtained from 12 pre-eclamptic and 34 physiological pregnancies. Another cohort of 10 healthy lactating women was established that was followed up for 6 months following delivery to investigate BAFF levels in breast milk. BAFF levels in maternal peripheral blood were significantly higher in physiological pregnancies than in pre-eclamptic pregnancies (p < 0.03). Furthermore, we observed a consistent presence of BAFF in breast milk during the 6-month post-partum period of breastfeeding. In this study, we demonstrate that BAFF levels are significantly lower in maternal peripheral blood in pre-eclamptic pregnancies. We also report the con-sistent presence of BAFF in breast milk in healthy women. More research into the role of BAFF in pregnancy, and during breastfeeding, is imperative.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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