Mechanisms of anterior gradient-2 regulation and function in cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000626" target="_blank" >RIV/00209805:_____/15:#0000626 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.semcancer.2015.04.005" target="_blank" >http://dx.doi.org/10.1016/j.semcancer.2015.04.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.semcancer.2015.04.005" target="_blank" >10.1016/j.semcancer.2015.04.005</a>

Result language
angličtina
Original language name
Mechanisms of anterior gradient-2 regulation and function in cancer
Original language description
Proteins targeted to secretory pathway enter the endoplasmic reticulum where they undergo posttranslational modification and subsequent quality control executed by exquisite catalysts of protein folding, protein disulphide isomerases (PDIs). These enzymes can often provide strict conformational protein folding solutions to highly cysteine-rich cargo as they facilitate disulphide rearrangement in the endoplasmic reticulum. Under conditions when PDI substrates are not isomerised properly, secreted proteins can accumulate in the endoplasmic reticulum leading to endoplasmic reticulum stress initiation with implications for human disease development. Anterior Gradient-2 (AGR2) is an endoplasmic reticulum-resident PDI superfamily member that has emerged as adominant effector of basic biological properties in vertebrates including blastoderm formation and limb regeneration. AGR2 perturbation in mammals influences disease processes including cancer progression and drug resistance, asthma, and
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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