p53-mediated control of gene expression via mRNA translation during Endoplasmic Reticulum stress
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000661" target="_blank" >RIV/00209805:_____/15:#0000661 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/15384101.2015.1090066" target="_blank" >http://dx.doi.org/10.1080/15384101.2015.1090066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15384101.2015.1090066" target="_blank" >10.1080/15384101.2015.1090066</a>
Alternative languages
Result language
angličtina
Original language name
p53-mediated control of gene expression via mRNA translation during Endoplasmic Reticulum stress
Original language description
p53 is activated by different stress and damage pathways and regulates cell biological responses including cell cycle arrest, repair pathways, apoptosis and senescence. Following DNA damage, the levels of p53 increase and via binding to target gene promoters, p53 induces expression of multiple genes including p21(CDKN1A) and mdm2. The effects of p53 on gene expression during the DNA damage response are well mimicked by overexpressing p53 under normal conditions. However, stress to the Endoplasmic Reticulum (ER) and the consequent Unfolded Protein Response (UPR) leads to the induction of the p53/47 isoform that lacks the first 40 aa of p53 and to an active suppression of p21(CDKN1A) transcription and mRNA translation. We now show that during ER stress p53 also suppresses MDM2 protein levels via a similar mechanism. These observations not only raise questions about the physiological role of MDM2 during ER stress but it also reveals a new facet of p53 as a repressor toward 2 of its major
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell cycle
ISSN
1538-4101
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
21
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
3373-3378
UT code for WoS article
000364559400011
EID of the result in the Scopus database
2-s2.0-84959491839