The source of MHC class I presented peptides and its implications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F16%3AN0000032" target="_blank" >RIV/00209805:_____/16:N0000032 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.coi.2016.04.002" target="_blank" >http://dx.doi.org/10.1016/j.coi.2016.04.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.coi.2016.04.002" target="_blank" >10.1016/j.coi.2016.04.002</a>

Result language
angličtina
Original language name
The source of MHC class I presented peptides and its implications
Original language description
The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was challenged by a model in which alternative translation products are a source of peptides. This model has been tested and supported by scientific data. We now need new hypotheses on the physiological implications of different sources of peptides for the MHCI pathway. The aim of this overview is to give an up-to-date account of the source of antigenic peptide material for the MHCI pathway and to incorporate the more recent observations of alternative mRNA translation products into existing models of the direct and cross-presentation pathways.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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