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AGR2 associates with HER2 expression predicting poor outcome in subset of estrogen receptor negative breast cancer patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077857" target="_blank" >RIV/00209805:_____/17:00077857 - isvavai.cz</a>

  • Result on the web

    <a href="https://linkinghub.elsevier.com/retrieve/pii/S0014-4800(16)30276-3" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S0014-4800(16)30276-3</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.yexmp.2017.02.016" target="_blank" >10.1016/j.yexmp.2017.02.016</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    AGR2 associates with HER2 expression predicting poor outcome in subset of estrogen receptor negative breast cancer patients

  • Original language description

    Expression of the AGR2 oncogenewas shown to be associated with estrogen receptor positive tumors. This gene contributes to enhanced cellular proliferation, drug resistance, metastasis development and may also serve as a predictor of poor prognosis. However, our analysis of AGR2 expression in a subset of estrogen-receptor negative tumors revealed that AGR2 could also be upregulated in hormone-independent manner. AGR2 expression was shown to be significantly increased in HER2 positive breast tumors on both the mRNA and the protein level. Moreover, in a subset of estrogen- and progesterone-receptor negative and simultaneously HER2-positive cases, increased AGR2 expression significantly correlated with worse patient prognosis. Subsequent analysis of independent data sets either collected in our institute or obtained from Oncomine cancer microarray database confirmed all these findings.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental and molecular pathology

  • ISSN

    0014-4800

  • e-ISSN

  • Volume of the periodical

    102

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    4

  • Pages from-to

    "280–283"

  • UT code for WoS article

    000403040200017

  • EID of the result in the Scopus database

    2-s2.0-85014107239