Bioelectrochemistry of nucleic acids for early cancer diagnostics – analysis of DNA methylation and detection of microRNAs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077932" target="_blank" >RIV/00209805:_____/17:00077932 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/view/j/revac.ahead-of-print/revac-2016-0022/revac-2016-0022.xml" target="_blank" >https://www.degruyter.com/view/j/revac.ahead-of-print/revac-2016-0022/revac-2016-0022.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/revac-2016-0022" target="_blank" >10.1515/revac-2016-0022</a>
Alternative languages
Result language
angličtina
Original language name
Bioelectrochemistry of nucleic acids for early cancer diagnostics – analysis of DNA methylation and detection of microRNAs
Original language description
Dysregulation of gene expression mechanisms has been observed in many tumors, making their analysis of utmost importance. These mechanisms include DNA methylation, an epigenetic mechanism in which 5-carbon of cytosine becomes methylated, leading to gene silencing, and action of short RNA molecules called microRNAs, which regulate protein synthesis at post-transcriptional level by binding to mRNAs. In this review, we describe major roles of both mechanisms in carcinogenesis, offer an overview of currently used methods for their analysis, and summarize most recent advances in electrochemicalbased assays and strategies. Advantages of electrochemistry, including favorable cost, time of experiment, or simple instrumentation, are highlighted, along with current challenges that need to be addressed prior to successful application into clinical routine.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Reviews in Analytical Chemistry
ISSN
0793-0135
e-ISSN
—
Volume of the periodical
36
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
20160022
UT code for WoS article
000396218200002
EID of the result in the Scopus database
2-s2.0-85016086101