Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078004" target="_blank" >RIV/00209805:_____/18:00078004 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00104694 RIV/00159816:_____/18:00068961
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043880/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043880/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/raon-2018-0023" target="_blank" >10.2478/raon-2018-0023</a>
Alternative languages
Result language
angličtina
Original language name
Radiotherapy of glioblastoma 15 years after the landmark Stupp’s trial: more controversies than standards?
Original language description
Background. The current standard of care of glioblastoma, the most common primary brain tumor in adults, has remained unchanged for over a decade. Nevertheless, some improvements in patient outcomes have occurred as a consequence of modern surgery, improved radiotherapy and up-to-date management of toxicity. Patients from control arms (receiving standard concurrent chemoradiotherapy and adjuvant chemotherapy with temozolomide) of recent clinical trials achieve better outcomes compared to the median survival of 14.6 months reported in Stupp's landmark clinical trial in 2005. The approach to radiotherapy that emerged from Stupp's trial, which continues to be a basis for the current standard of care, is no longer applicable and there is a need to develop updated guidelines for radiotherapy within the daily clinical practice that address or at least acknowledge existing controversies in the planning of radiotherapy. The goal of this review is to provoke critical thinking about potentially controversial aspects in the radiotherapy of glioblastoma, including among others the issue of target definitions, simultaneously integrated boost technique, and hippocampal sparing. Conclusions. In conjunction with new treatment approaches such as tumor-treating fields (TTF) and immunotherapy, the role of adjuvant radiotherapy will be further defined. The personalized approach in daily radiotherapy practice is enabled with modern radiotherapy systems.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiology and oncology
ISSN
1318-2099
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
2
Country of publishing house
SI - SLOVENIA
Number of pages
8
Pages from-to
121-128
UT code for WoS article
000433103400001
EID of the result in the Scopus database
2-s2.0-85048757842