HLA class I and II diversity contributes to the etiologic heterogeneity of non-Hodgkin lymphoma subtypes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078017" target="_blank" >RIV/00209805:_____/18:00078017 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00106857
Result on the web
<a href="http://cancerres.aacrjournals.org/content/78/14/4086.full-text.pdf" target="_blank" >http://cancerres.aacrjournals.org/content/78/14/4086.full-text.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1158/0008-5472.CAN-17-2900" target="_blank" >10.1158/0008-5472.CAN-17-2900</a>
Alternative languages
Result language
angličtina
Original language name
HLA class I and II diversity contributes to the etiologic heterogeneity of non-Hodgkin lymphoma subtypes
Original language description
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL 1/4 1.31, 95% CI 1/4 1.06-1.60; OR MZL 1/4 1.45, 95% CI 1/4 1.12-1.89) and class II HLA-DRB1 locus (OR DLBCL 1/4 2.10, 95% CI 1/4 1.24-3.55; OR MZL 1/4 2.10, 95% CI 1/4 0.99-4.45). Increased FL risk was observed with the overall increase in number of homozygous HLA class II loci (P trend < 0.0001, FDR 1/4 0.0005). These results support a role for HLA zygosity in NHL etiology and suggests that distinct immune pathways may underly the etiology of the different NHL subtypes. Significance: HLA gene diversity reduces risk for non-Hodgkin lymphoma.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer research
ISSN
0008-5472
e-ISSN
—
Volume of the periodical
78
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
4086-4096
UT code for WoS article
000439199100028
EID of the result in the Scopus database
2-s2.0-85050829279