Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078038" target="_blank" >RIV/00209805:_____/18:00078038 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/18:00068914 RIV/00159816:_____/18:00068914 RIV/00216224:14110/18:00106939

Result on the web

<a href="http://cgp.iiarjournals.org/content/15/4/321.long" target="_blank" >http://cgp.iiarjournals.org/content/15/4/321.long</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/cgp.20090" target="_blank" >10.21873/cgp.20090</a>

Result language

angličtina

Original language name

Pre-operative Plasma miR-21-5p Is a Sensitive Biomarker and Independent Prognostic Factor in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgical Resection

Original language description

Blood plasma microRNAs (miRNAs) are emerging as a clinically useful tool for non-invasive detection and prognosis estimation in various cancer types including pancreatic ductal adenocarcinoma (PDAC). The aim of the present study was to provide an independent validation of circulating miRNAs identified in previous studies as diagnostic and/or prognostic biomarkers in PDAC. Based on the literature search, 6 miRNAs were chosen as candidates for independent validation; miR-21-5p, miR-375, miR-155, miR-17-5p, miR-126-5p and miR-1290. Validation of these miRNAs was performed in a cohort of 25 patients with PDAC undergoing surgical resection and 24 healthy donors. Plasma levels of miRNAs were determined using quantitative real-time PCR. We confirmed significantly higher levels of all tested miRNA in blood plasma of PDAC patients in comparison to healthy controls with miR-21-5p showing the highest analytical performance (p&lt;0.001; AUC&gt;0.99). Increased levels of miR-21-5p (p=0.045) and miR-375 (p=0.013) were significantly associated with overall survival. Multivariate analysis demonstrated that miR-21-5p is a significant unfavorable prognostic factor independent on other clinical variables including adjuvant chemotherapy (hazard ratio 2.95; 95% CI 1.06-8.18; p=0.038). Our preliminary data indicate promising diagnostic and prognostic utility of plasma miR-21-5p in PDAC patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

—

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Genomics and Proteomics

ISSN

1109-6535

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

4

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

321-327

UT code for WoS article

000437932600010

EID of the result in the Scopus database

2-s2.0-85049867382