Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078053" target="_blank" >RIV/00209805:_____/18:00078053 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15120/18:73594998
Result on the web
<a href="http://www.nature.com/articles/mp201788" target="_blank" >http://www.nature.com/articles/mp201788</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/mp.2017.88" target="_blank" >10.1038/mp.2017.88</a>
Alternative languages
Result language
angličtina
Original language name
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
Original language description
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P = 9.89 x 10(-6)), and rs7700147, an intergenic variant (P = 2.93 x 10(-5)). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular psychiatry
ISSN
1359-4184
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1169-1180
UT code for WoS article
000431614600009
EID of the result in the Scopus database
2-s2.0-85029816710