Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078097" target="_blank" >RIV/00209805:_____/18:00078097 - isvavai.cz</a>

Result on the web

<a href="https://www.hindawi.com/journals/bmri/2018/2459608/" target="_blank" >https://www.hindawi.com/journals/bmri/2018/2459608/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2018/2459608" target="_blank" >10.1155/2018/2459608</a>

Result language

angličtina

Original language name

Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy

Original language description

Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury. Accumulating data are showing different postradiotherapy changes in the left and right hippocampus with a theoretical proposal of only unilateral (dominant, left) hippocampal sparing during WBRT. Method. The aim of this retrospective study is to describe spatial distribution of brainmetastases on MRI in a cohort of 260 patients (2595metastases) and to evaluate distribution separately in the left and right hippocampus and in respective hippocampal avoiding zones (HAZ, region with subtherapeutic radiation dose), including evaluation of location of metastatic mass centre. Results.The median number of brain metastases was three, with lung cancer being the most common type of primary tumour; 36% had single metastasis. Almost 8% of patients had metastasis within hippocampus (1.1%of allmetastases) and 18.1%of patientswithinHAZ (3.3% of allmetastases).No statistically significant difference was observed in the laterality of hippocampal involvement, also when the location of centre of metastases was analyzed. There were more patients presenting the centre of metastasis within left (15) versus right (6) HAZ approaching the borderline of statistical significance. Conclusion. No significant difference in the laterality of BM seeding within hippocampal structures was observed. The hypothesized unilateral sparing WBRT would have theoretical advantage in about 50% reduction in the risk of subsequent recurrence within spared regions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BioMed research international [online]

ISSN

2314-6141

e-ISSN

—

Volume of the periodical

2018

Issue of the periodical within the volume

2018

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

2459608

UT code for WoS article

000460311500001

EID of the result in the Scopus database

2-s2.0-85059800692