Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078063" target="_blank" >RIV/00209805:_____/19:00078063 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587711/pdf/JOP-48-24.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587711/pdf/JOP-48-24.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jop.12792" target="_blank" >10.1111/jop.12792</a>
Alternative languages
Result language
angličtina
Original language name
Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
Original language description
Background: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. Materials and methods: To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (LESS-THAN OR EQUAL TO40 years) and five elderly patients (GREATER-THAN OR EQUAL TO50 years) using global RNA sequencing and whole-exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. Results: In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low-CNV (n = 5) compared to high-CNV (n = 11) burden (P = 0.044). Conclusions: Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of oral pathology & medicine
ISSN
0904-2512
e-ISSN
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Volume of the periodical
48
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
24-30
UT code for WoS article
000454799800005
EID of the result in the Scopus database
2-s2.0-85055957580