The p53 mRNA: an integral part of the cellular stress response
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078127" target="_blank" >RIV/00209805:_____/19:00078127 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468297/pdf/gkz124.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468297/pdf/gkz124.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkz124" target="_blank" >10.1093/nar/gkz124</a>
Alternative languages
Result language
angličtina
Original language name
The p53 mRNA: an integral part of the cellular stress response
Original language description
A large number of signalling pathways converge on p53 to induce different cellular stress responses that aim to promote cell cycle arrest and repair or, if the damage is too severe, to induce irreversible senescence or apoptosis. The differentiation of p53 activity towards specific cellular outcomes is tightly regulated via a hierarchical order of post-translational modifications and regulated protein-protein interactions. The mechanisms governing these processes provide amodel for how cells optimize the genetic information for maximal diversity. The p53 mRNA also plays a role in this process and this review aims to illustrate how protein and RNA interactions throughout the p53 mRNA in response to different signalling pathways control RNA stability, translation efficiency or alternative initiation of translation. We also describe how a p53 mRNA platform shows riboswitchlike features and controls the rate of p53 synthesis, protein stability and modifications of the nascent p53 protein. A single cancer-derived synonymous mutation disrupts the folding of this platform and prevents p53 activation following DNA damage. The role of the p53 mRNA as a target for signalling pathways illustrates how mRNA sequences have co-evolved with the function of the encoded protein and sheds new light on the information hidden within mRNAs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic acids research
ISSN
0305-1048
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
"3257–3271"
UT code for WoS article
000467965900007
EID of the result in the Scopus database
2-s2.0-85064990825