Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078233" target="_blank" >RIV/00209805:_____/19:00078233 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/19:73594990 RIV/61989592:15120/19:73594990 RIV/00216208:11110/19:10400057
Result on the web
<a href="https://www.nature.com/articles/s41588-019-0439-2.pdf" target="_blank" >https://www.nature.com/articles/s41588-019-0439-2.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41588-019-0439-2" target="_blank" >10.1038/s41588-019-0439-2</a>

Result language
angličtina
Original language name
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Original language description
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
<a href="/en/project/NV17-28905A" target="_blank" >NV17-28905A: The Role of Gut Microbiome and Autoimmune Mechanisms in Patients with Anorexia Nervosa</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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