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Peptide Channeling: The Key to MHC Class I Immunosurveillance?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078329" target="_blank" >RIV/00209805:_____/19:00078329 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/abs/pii/S096289241930162X" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S096289241930162X</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.tcb.2019.09.004" target="_blank" >10.1016/j.tcb.2019.09.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Peptide Channeling: The Key to MHC Class I Immunosurveillance?

  • Original language description

    MHC class I presentation of short peptides enables CD8+ T cell (TCD8+) immunosurveillance of tumors and intracellular pathogens. A key feature of the class I pathway is that the immunopeptidome is highly skewed from the cellular degradome, indicating high selectivity of the access of protease-generated peptides to class I molecules. Similarly, in professional antigen-presenting cells, peptides from minute amounts of proteins introduced into the cytosol outcompete an overwhelming supply of constitutively generated peptides. Here, we propose that antigen processing is based on substrate channeling and review recent studies from the antigen processing and cell biology fields that provide a starting point for testing this hypothesis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Trends in cell biology

  • ISSN

    0962-8924

  • e-ISSN

  • Volume of the periodical

    29

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

    929-939

  • UT code for WoS article

    000497668700001

  • EID of the result in the Scopus database

    2-s2.0-85074386892