Peptide Channeling: The Key to MHC Class I Immunosurveillance?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078329" target="_blank" >RIV/00209805:_____/19:00078329 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S096289241930162X" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S096289241930162X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tcb.2019.09.004" target="_blank" >10.1016/j.tcb.2019.09.004</a>
Alternative languages
Result language
angličtina
Original language name
Peptide Channeling: The Key to MHC Class I Immunosurveillance?
Original language description
MHC class I presentation of short peptides enables CD8+ T cell (TCD8+) immunosurveillance of tumors and intracellular pathogens. A key feature of the class I pathway is that the immunopeptidome is highly skewed from the cellular degradome, indicating high selectivity of the access of protease-generated peptides to class I molecules. Similarly, in professional antigen-presenting cells, peptides from minute amounts of proteins introduced into the cytosol outcompete an overwhelming supply of constitutively generated peptides. Here, we propose that antigen processing is based on substrate channeling and review recent studies from the antigen processing and cell biology fields that provide a starting point for testing this hypothesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in cell biology
ISSN
0962-8924
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
929-939
UT code for WoS article
000497668700001
EID of the result in the Scopus database
2-s2.0-85074386892