Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078517" target="_blank" >RIV/00209805:_____/20:00078517 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/20:00118388 RIV/65269705:_____/20:00073978
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/33378673/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33378673/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2020.108552" target="_blank" >10.1016/j.celrep.2020.108552</a>
Alternative languages
Result language
angličtina
Original language name
Charting Extracellular Transcriptomes in The Human Biofluid RNA Atlas
Original language description
Extracellular RNAs present in biofluids have emerged as potential biomarkers for disease. Where most studies focus on blood-derived fluids, other biofluids may be more informative. We present an atlas of messenger, circular, and small RNA transcriptomes of a comprehensive collection of 20 human biofluids. By means of synthetic spike-in controls, we compare RNA content across biofluids, revealing a 10,000-fold difference in concentration. The circular RNA fraction is increased in most biofluids compared to tissues. Each biofluid transcriptome is enriched for RNA molecules derived from specific tissues and cell types. Our atlas enables an informed selection of the most relevant biofluid to monitor particular diseases. To verify the biomarker potential in these biofluids, four validation cohorts representing a broad spectrum of diseases were profiled, revealing numerous differential RNAs between case and control subjects. Spike-normalized data are publicly available in the R2 web portal for further exploration.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
108552
UT code for WoS article
000604449500006
EID of the result in the Scopus database
2-s2.0-85098622623