Interpretive discrepancies caused by target values inter‐batch variations in chemiluminescence immunoassay for SARS‐CoV‐2 IgM/IgG by MAGLUMI
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F21%3A00078471" target="_blank" >RIV/00209805:_____/21:00078471 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/20:00073377 RIV/65269705:_____/21:00074236
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.26612" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.26612</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jmv.26612" target="_blank" >10.1002/jmv.26612</a>
Alternative languages
Result language
angličtina
Original language name
Interpretive discrepancies caused by target values inter‐batch variations in chemiluminescence immunoassay for SARS‐CoV‐2 IgM/IgG by MAGLUMI
Original language description
Plasma specimens from coronavirus disease 2019 patients were double-tested for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies by two different batches of MAGLUMI 2019-nCov immunoglobulin M/immunoglobulinG (IgM/IgG) assays to evaluate IgM/IgG levels, qualitative interpretation, antibody kinetics, and linearity of diluted specimen. Here we show that (i) high-level IgM specimens need to be diluted with negative human plasma but not kit diluents and(ii) measured anti-SARS-CoV-2 IgM/IgG concentrations are substantially higher with later marketed immunoassay batch leading to (iii) the change of qualitative interpretation (positive vs. negative) in 12.3% of specimens measured for IgM, (iv) the informative time-course pattern of antibody production only when data from different immunoassay batches are not combined.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/LM2018125" target="_blank" >LM2018125: Bank of Clinical Samples</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of medical virology
ISSN
0146-6615
e-ISSN
—
Volume of the periodical
93
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1805-1809
UT code for WoS article
000583206600001
EID of the result in the Scopus database
2-s2.0-85094640715