circFOXO3: Going around the mechanistic networks in cancer by interfering with miRNAs regulatory networks
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F21%3A00078556" target="_blank" >RIV/00209805:_____/21:00078556 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/21:00124304
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0925443920303938?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0925443920303938?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbadis.2020.166045" target="_blank" >10.1016/j.bbadis.2020.166045</a>
Alternative languages
Result language
angličtina
Original language name
circFOXO3: Going around the mechanistic networks in cancer by interfering with miRNAs regulatory networks
Original language description
Circular RNAs (circRNA) have gained recent interest due to their functional versatility due to their interactions with other RNA species and proteins, all of which underline complex regulatory networks involved in pathogenic mechanisms. As a result, recent insights in circRNA biology are investigating their biomarker and therapeutic potential. One such circRNA is CircFOXO3, which consists of the circularized second exon of the FOXO3 mRNA, a member of the forkhead box transcription factor family involved in the regulation of developmental programs. Recent research focused on the role of circFOXO3 in the context of cancer has highlighted several implications in key tumorigenesis mechanisms, thus consolidating its relevance among other identified circRNAs. In this paper, we will focus on the currently identified case-specific implications of circFOXO3 in cancer, with a focus on the circFOXO3-miRNA-mRNA regulatory networks, its interactions with different proteins, and their cumulated biological effects upon tumor development. Therefore, we aim to provide an integrated perspective of the mechanistic implications of circFOXO3 in different cancers while also highlighting its biomarker or therapeutic potential based on the current evidence.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica et biophysica acta. Molecular basis of disease
ISSN
0925-4439
e-ISSN
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Volume of the periodical
1867
Issue of the periodical within the volume
5
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
166045
UT code for WoS article
000632563900002
EID of the result in the Scopus database
2-s2.0-85100405713