The efficiency of antineoplastic drug contamination removal by widely used disinfectants-laboratory and hospital studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F21%3A00078571" target="_blank" >RIV/00209805:_____/21:00078571 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/21:00075851 RIV/00216224:14310/21:00120136

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/33738516/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33738516/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00420-021-01671-5" target="_blank" >10.1007/s00420-021-01671-5</a>

Result language

angličtina

Original language name

The efficiency of antineoplastic drug contamination removal by widely used disinfectants-laboratory and hospital studies

Original language description

Objective: Antineoplastic drugs (ADs) pose risks to healthcare staff. Surface disinfectants are used in hospitals to prevent microbial contamination but the efficiency of disinfectants to degrade ADs is not known. We studied nine disinfectants on ten ADs in the standardized laboratory and realistic in situ hospital conditions. Methods: A survey in 43 hospitals prioritized nine most commonly used disinfections based on different ingredients. These were tested on inert stainless steel and in situ on contaminated hospital flooring. The effects against ten ADs were studied by LC-MS/MS (Cyclophosphamide CP; Ifosfamide IF; Capecitabine CAP; Sunitinib SUN; Methotrexate MET; Doxorubicin DOX; Irinotecan IRI; Paclitaxel PX; 5-Fluorouracil FU) and ICP-MS (Pt as a marker of platinum-based ADs). Results: Monitoring of the floor contamination in 26 hospitals showed that the most contaminated are the outpatient clinics that suffer from a large turnover of staff and patients and have limited preventive measures. The most frequent ADs were Pt, PX, FU and CP with maxima exceeding the recommended 1 ng/cm2 limit by up to 140 times. IRI, FU, MET, DOX and SUN were efficiently removed by hydrolysis in clean water and present thus lower occupational risk. Disinfectants based on hydrogen peroxide were efficient against PX and FU (&gt; 70% degradation) but less against other ADs, such as carcinogenic CP or IF, IRI and CAP. The most efficient were the active chlorine and peracetic acid-based products, which however release irritating toxic vapors. The innovative in situ testing of ADs previously accumulated in hospital flooring showed highly problematic removal of carcinogenic CP and showed that alcohol-based disinfectants may mobilize persistent ADs contamination from deeper floor layers. Conclusion: Agents based on hydrogen peroxide, peracetic acid, quaternary ammonium salts, glutaraldehyde, glucoprotamine or detergents can be recommended for daily use for both disinfection and AD decontamination. However, they have variable efficiencies and should be supplemented by periodic use of strong chlorine-based disinfectants efficient also against the carcinogenic and persistent CP.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

—

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International archives of occupational and environmental health

ISSN

0340-0131

e-ISSN

—

Volume of the periodical

94

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

16

Pages from-to

1687-1702

UT code for WoS article

000630269700001

EID of the result in the Scopus database

2-s2.0-85102997446