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Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F21%3A00078982" target="_blank" >RIV/00209805:_____/21:00078982 - isvavai.cz</a>

  • Result on the web

    <a href="https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8521875&blobtype=pdf" target="_blank" >https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC8521875&blobtype=pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1093/ije/dyab042" target="_blank" >10.1093/ije/dyab042</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer

  • Original language description

    Background: Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases. Methods: We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Higher CLL-PRS was associated with increased BCC risk (OR4th- quartile-vs-1stquartile = 1.13, 95% CI: 1.02-1.24, P-trend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (P-trend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th- quartile-vs-1st-quartile = 1.22, 95% CI: 1.08-1.38, P-trend = 1.36 x 10(-5)), which was driven by shared genetic susceptibility at the 6p25.3 locus. Conclusion: These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International journal of epidemiology

  • ISSN

    0300-5771

  • e-ISSN

  • Volume of the periodical

    50

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    1325-1334

  • UT code for WoS article

    000705268900032

  • EID of the result in the Scopus database

    2-s2.0-85115938241