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The different activities of RNA G-quadruplex structures are controlled by flanking sequences

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F22%3A00078891" target="_blank" >RIV/00209805:_____/22:00078891 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.life-science-alliance.org/content/5/2/e202101232" target="_blank" >https://www.life-science-alliance.org/content/5/2/e202101232</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.26508/lsa.202101232" target="_blank" >10.26508/lsa.202101232</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The different activities of RNA G-quadruplex structures are controlled by flanking sequences

  • Original language description

    The role of G-quadruplex (G4) RNA structures is multifaceted and controversial. Here, we have used as a model the EBV-encoded EBNA1 and the Kaposi&apos;s sarcoma-associated herpesvirus (KSHV)-encoded LANA1 mRNAs. We have compared the G4s in these two messages in terms of nucleolin binding, nuclear mRNA retention, and mRNA translation inhibition and their effects on immune evasion. The G4s in the EBNA1 message are clustered in one repeat sequence and the G4 ligand PhenDH2 prevents all G4-associated activities. The RNA G4s in the LANA1 message take part in similar multiple mRNA functions but are spread throughout the message. The different G4 activities depend on flanking coding and non-coding sequences and, interestingly, can be separated individually. Together, the results illustrate the multifunctional, dynamic and context-dependent nature of G4 RNAs and highlight the possibility to develop ligands targeting specific RNA G4 functions. The data also suggest a common multifunctional repertoire of viral G4 RNA activities for immune evasion.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molecular, cellular and clinical approach to healthy ageing</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Life Science Alliance

  • ISSN

    2575-1077

  • e-ISSN

    2575-1077

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    "e202101232"

  • UT code for WoS article

    000720480300001

  • EID of the result in the Scopus database

    2-s2.0-85120752219