Immune-Mediated Adverse Effects of Checkpoint Inhibitors: A Clinical Experience
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F22%3A00079078" target="_blank" >RIV/00209805:_____/22:00079078 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/22:00128009
Result on the web
<a href="https://sciendo.com/pdf/10.2478/afpuc-2022-0006" target="_blank" >https://sciendo.com/pdf/10.2478/afpuc-2022-0006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/afpuc-2022-0006" target="_blank" >10.2478/afpuc-2022-0006</a>
Alternative languages
Result language
angličtina
Original language name
Immune-Mediated Adverse Effects of Checkpoint Inhibitors: A Clinical Experience
Original language description
Autoimmune adverse effects of immune checkpoint inhibitors (ICIs) are rare but may be life-threatening. We performed a retrospective analysis of the immune-related adverse effects (irAEs) of ICIs in the Masaryk Memorial Cancer Institute (MMCI) from 2011 to 2021. The ICIs were administered to 648 patients. Severe irAEs were pronounced in 83 patients (12.8 %). Further, we report a case of severe irAE after treatment with ipilimumab and nivolumab. Prednisone, mesalazine, octreotide, infliximab, vedolizumab, and mycophenolate mofetil were used to manage G4 colitis, with partial response. Early diagnosis and appropriate management of irAE are essential in the perspective of further oncological treatment.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Pharmaceutical Journal
ISSN
2453-6725
e-ISSN
2453-6725
Volume of the periodical
69
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
3
Pages from-to
84-86
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85136909996