Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F22%3A00079085" target="_blank" >RIV/00209805:_____/22:00079085 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41375-022-01711-0" target="_blank" >https://www.nature.com/articles/s41375-022-01711-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41375-022-01711-0" target="_blank" >10.1038/s41375-022-01711-0</a>

Result language

angličtina

Original language name

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes

Original language description

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P &lt; 5 x 10(-8)) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 x 10(-9)). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P &lt; 5 x 10(-8)), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

LEUKEMIA

ISSN

0887-6924

e-ISSN

1476-5551

Volume of the periodical

36

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

2835-2844

UT code for WoS article

000871170900001

EID of the result in the Scopus database

2-s2.0-85140325134