Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079648" target="_blank" >RIV/00209805:_____/24:00079648 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10478679 RIV/61989592:15110/24:73626620
Result on the web
<a href="https://www.sjweh.fi/article/4140" target="_blank" >https://www.sjweh.fi/article/4140</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5271/sjweh.4140" target="_blank" >10.5271/sjweh.4140</a>
Alternative languages
Result language
angličtina
Original language name
Respirable crystalline silica and lung cancer in community-based studies: impact of job-exposure matrix specifications on exposure-response relationships
Original language description
Objectives The quantitative job -exposure matrix SYN-JEM consists of various dimensions: job -specific estimates, region -specific estimates, and prior expert ratings of jobs by the semi -quantitative DOM-JEM. We analyzed the effect of different JEM dimensions on the exposure-response relationships between occupational silica exposure and lung cancer risk to investigate how these variations influence estimates of exposure by a quantitative JEM and associated health endpoints. Methods Using SYN-JEM, and alternative SYN-JEM specifications with varying dimensions included, cumulative silica exposure estimates were assigned to 16 901 lung cancer cases and 20 965 controls pooled from 14 international community -based case -control studies. Exposure-response relationships based on SYN-JEM and alternative SYN-JEM specifications were analyzed using regression analyses (by quartiles and log -transformed continuous silica exposure) and generalized additive models (GAM), adjusted for age, sex, study, cigarette pack -years, time since quitting smoking, and ever employment in occupations with established lung cancer risk. Results SYN-JEM and alternative specifications generated overall elevated and similar lung cancer odds ratios ranging from 1.13 (1st quartile) to 1.50 (4th quartile). In the categorical and log -linear analyses SYN-JEM with all dimensions included yielded the best model fit, and exclusion of job -specific estimates from SYN-JEM yielded the poorest model fit. Additionally, GAM showed the poorest model fit when excluding job -specific estimates. Conclusion The established exposure-response relationship between occupational silica exposure and lung cancer was marginally influenced by varying the dimensions of SYN-JEM. Optimized modelling of exposure-response relationships will be obtained when incorporating all relevant dimensions, namely prior rating, job, time, and region. Quantitative job -specific estimates appeared to be the most prominent dimension for this general population JEM.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scandinavian journal of work, environment & health
ISSN
0355-3140
e-ISSN
1795-990X
Volume of the periodical
50
Issue of the periodical within the volume
3
Country of publishing house
FI - FINLAND
Number of pages
9
Pages from-to
178-186
UT code for WoS article
001155770600001
EID of the result in the Scopus database
2-s2.0-85189192041