Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079763" target="_blank" >RIV/00209805:_____/24:00079763 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00136239 RIV/65269705:_____/24:00080339

Result on the web

<a href="https://journals.viamedica.pl/rpor/article/view/99362" target="_blank" >https://journals.viamedica.pl/rpor/article/view/99362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/rpor.99362" target="_blank" >10.5603/rpor.99362</a>

Result language

angličtina

Original language name

Adjuvant radiotherapy after brain metastasectomy: analysis of consecutive cohort of 118 patients from real world practice

Original language description

Background: The aim of this retrospective study is to analyze a consecutive cohort of brain metastasis (BM) patients treatedoff clinical trials through combination of surgery and radiotherapy over the last 15 years in a tertiary neurooncology center.Materials and methods: All BM patients operated between 2007-2019 received adjuvant linac-based radiotherapy categorizedto whole brain radiotherapy (WBRT) and tumor bed stereotactic radiotherapy. Survival outcomes and local control was analyzed.Results: In total, 118 patients were enrolled, those with stereotactic radiotherapy (41%) had better baseline characteristics mirrored in longer overall survival (OS) [18 vs. 7.1 months, p &lt; 0.001; hazard ratio (HR) 0.47, p = 0.004] with median follow-up of 58 months. Cumulative incidence for local, distant, and extracranial control was not significantly different betweengroups, with 12-month cumulative control of 22% vs. 18%, 44% vs. 29%, and 35% vs. 32% for stereotactic and WBRT group,respectively. WBRT was an independent factor for better distal brain control.Conclusions: Real world data demonstrating significantly better overall survival in patients treated with postoperative targeted radiotherapy compared with postoperative WBRT is presented, with no significant difference in cumulative incidencefor local or distant brain control. The majority of patients with targeted radiotherapy had a fractionated dose schedule withoutcomes comparable to single-dose radiation trials of postoperative targeted radiotherapy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Reports of Practical Oncology and Radiotherapy

ISSN

1507-1367

e-ISSN

2083-4640

Volume of the periodical

29

Issue of the periodical within the volume

1

Country of publishing house

PL - POLAND

Number of pages

12

Pages from-to

30-41

UT code for WoS article

001293214500001

EID of the result in the Scopus database

2-s2.0-85188780134