Geographic variation of mutagenic exposures in kidney cancer genomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079772" target="_blank" >RIV/00209805:_____/24:00079772 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/24:10479864 RIV/00216208:11130/24:10479864 RIV/00064203:_____/24:10479864

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11111402/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11111402/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41586-024-07368-2" target="_blank" >10.1038/s41586-024-07368-2</a>

Result language

angličtina

Original language name

Geographic variation of mutagenic exposures in kidney cancer genomes

Original language description

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden(1). In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence(2). Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations. Here we sequenced 962 clear cell renal cell carcinomas from 11 countries with varying incidence. The somatic mutation profiles differed between countries. In Romania, Serbia and Thailand, mutational signatures characteristic of aristolochic acid compounds were present in most cases and but these were rare elsewhere. In Japan, a mutational signature of unknown cause was found in more than 70% of cases but in less than 2% elsewhere. A further mutational signature of unknown cause was ubiquitous but exhibited higher mutation loads in countries with higher incidence rates of kidney cancer. Known signatures of tobacco smoking correlated with tobacco consumption, but no signature was associated with obesity or hypertension, suggesting that non-mutagenic mechanisms of action underlie these risk factors. The results of this study indicate the existence of multiple, geographically variable, mutagenic exposures that potentially affect tens of millions of people and illustrate the opportunities for new insights into cancer causation through large-scale global cancer genomics.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature

ISSN

0028-0836

e-ISSN

1476-4687

Volume of the periodical

629

Issue of the periodical within the volume

8013

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

910-918

UT code for WoS article

001216226800006

EID of the result in the Scopus database

2-s2.0-85192020403