Trends in the treatment of human papillomavirus-associated oropharyngeal carcinoma in Slovakia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079956" target="_blank" >RIV/00209805:_____/24:00079956 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/24:00137095

Result on the web

<a href="https://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8402&category_id=196&option=com_virtuemart&Itemid=12" target="_blank" >https://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=8402&category_id=196&option=com_virtuemart&Itemid=12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2024_240306N96" target="_blank" >10.4149/neo_2024_240306N96</a>

Result language

angličtina

Original language name

Trends in the treatment of human papillomavirus-associated oropharyngeal carcinoma in Slovakia

Original language description

The optimal treatment of oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) is currently asubject of clinical research. This questionnaire study investigated current trends in the treatment of HPV-associated (HPV+)OPC in Slovakia with the incorporation of deintensification of oncological treatment into routine clinical practice outsideof clinical trials. The Slovak Cooperative Head and Neck Cancer Group (SCHNCG) developed a questionnaire aimed atidentifying trends in the oncological treatment of HPV+ OPC intended for all radiation oncology (RO) facilities in Slovakia.Specialists in the field of RO responded to general questions about the character of their individual institutions as well asto 4 theoretical clinical scenarios (case reports) regarding the treatment of HPV+ OPC, focusing primarily on the applieddose of radiotherapy (RT), the extent of target volumes, and the type of concurrent chemotherapy (CHT). The questionnairestudy involved 35 RO specialists from 14 institutions in Slovakia. Regarding primary chemoradiotherapy (CRT) in T1N1M0HPV+ OPC, 16 respondents (45.7%) would consider de-escalation of the RT dose to &lt;70 Gy. In the case of postoperativeRT in pT1pN1M0 HPV+ OPC with negative resection margins (R0) and absent extracapsular extension (ECE), 4 physicians(11.4%) would consider de-escalation of the RT dose to &lt;60 Gy in the tumor bed area, while the majority of the treatingspecialists (n=19, 54.3%) would omit concurrent CHT. In the case of primary RT in elderly patient with T2N1M0 HPV+OPC, the same number of physicians (n=16, 45.7%) would consider de-escalation of the RT dose to &lt;70 Gy, and 14 respondents(40.0%) would completely omit CHT. In a high-risk patient with T2N3M0 HPV+ OPC with a complete response after3 cycles of induction chemotherapy (iCHT), none of the respondents would indicate a reduction in the RT dose to the areaof the original tumor and lymphadenopathy to &lt;60 Gy. The doses and extent of irradiated volumes in the treatment of HPV+OPC in Slovakia vary among different institutions. The tendency to de-escalate RT doses and reduce doses of concurrentsystemic therapy in Slovakia is high and there was also an observed trend to reduce the extent of radiation treatment fields.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NU22-03-00435" target="_blank" >NU22-03-00435: FMISO-based protocol for adaptive radiotherapy in head and neck cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

1338-4317

Volume of the periodical

71

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

12

Pages from-to

402-413

UT code for WoS article

001335526400009

EID of the result in the Scopus database

2-s2.0-85204167573