Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00079820" target="_blank" >RIV/00209805:_____/25:00079820 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00140241 RIV/65269705:_____/25:00079992
Result on the web
<a href="https://biomed.papers.upol.cz/artkey/bio-202503-0005_enhancing-the-utility-of-chromosome-6-and-8-testing-in-uveal-melanoma-biopsies.php" target="_blank" >https://biomed.papers.upol.cz/artkey/bio-202503-0005_enhancing-the-utility-of-chromosome-6-and-8-testing-in-uveal-melanoma-biopsies.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2024.018" target="_blank" >10.5507/bp.2024.018</a>
Alternative languages
Result language
angličtina
Original language name
Enhancing the utility of chromosome 6 and 8 testing in uveal melanoma biopsies
Original language description
BACKGROUND: The aim of this study was to evaluate the significance of testing the gain of chromosome 8 and the gain of chromosome 6 as prognostic markers in histopathological samples of enucleated eyes in with uveal melanoma. METHODS: This is a retrospective study of 54 enucleated eyes. The status of chromosomes 3, 8 and 6 was tested by CISH, and FISH was used in a few samples. A follow-up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was determined. RESULTS: The study group consists of 54 patients (average age 63 years), 28 men (51.9%) Monosomy 3 together with gain of chromosome 8 was found in 10 samples (18.5%). Both chromosomal abnormalities were detected in 6 (11%) patients. No chromosomal abnormality in 3 or 8 was detected in 21 (38.9%) patients. Abnormalities of chromosome 6 were present in 6 (11%) patients. Progression free survival after 5 years was 33.3% (95% CI 0.0; 83.3) in these patients. CONCLUSIONS: Our findings indicate a correlation between progression-free survival and the presence of changes in chromosome 3 and e 8 in uveal melanomas. The results underline the necessity of testing for both chromosomal aberrations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
ISSN
1213-8118
e-ISSN
1804-7521
Volume of the periodical
169
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
196-202
UT code for WoS article
001238711300001
EID of the result in the Scopus database
2-s2.0-105016793475