HER2 Status in Low-grade Serous Ovarian Tumors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00079951" target="_blank" >RIV/00209805:_____/25:00079951 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10484144 RIV/00216208:11120/25:43927516 RIV/00216208:11130/25:10484144 RIV/00216208:11150/25:10484144 and 4 more
Result on the web
<a href="https://journals.lww.com/intjgynpathology/abstract/2025/07000/her2_status_in_low_grade_serous_ovarian_tumors.5.aspx" target="_blank" >https://journals.lww.com/intjgynpathology/abstract/2025/07000/her2_status_in_low_grade_serous_ovarian_tumors.5.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PGP.0000000000001059" target="_blank" >10.1097/PGP.0000000000001059</a>
Alternative languages
Result language
angličtina
Original language name
HER2 Status in Low-grade Serous Ovarian Tumors
Original language description
Using immunohistochemistry, we examined a large cohort of 135 ovarian tumors, made up of 96 low-grade serous carcinomas (LGSCs) and 39 serous borderline tumors (micropapillary variant, mSBT), with the aim of exploring their HER2 status (overexpression). We followed with comprehensive genomic analyses on this sample set from our previous study, which revealed HER2 mutation in 5% (4/75) of LGSC and 10% (3/29) of mSBT. No cases were evaluated as HER2-positive, but 6 LGSCs and 1 mSBT were scored as HER2 1+, and 2 LGSCs and 1 mSBT showed the so-called HER2 "ultra-low" phenotype. This could be of clinical value as a potential therapeutical target concerning emerging therapeutic treatments (antibody conjugates). However, the clinical significance of this expression still needs to be established.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International journal of gynecological pathology
ISSN
0277-1691
e-ISSN
1538-7151
Volume of the periodical
44
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
331-335
UT code for WoS article
001508074300010
EID of the result in the Scopus database
2-s2.0-85203239195