Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080083" target="_blank" >RIV/00209805:_____/25:00080083 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00140408 RIV/61989100:27240/25:10256933 RIV/65269705:_____/25:00080738
Result on the web
<a href="https://link.springer.com/article/10.1007/s00270-024-03908-5" target="_blank" >https://link.springer.com/article/10.1007/s00270-024-03908-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00270-024-03908-5" target="_blank" >10.1007/s00270-024-03908-5</a>
Alternative languages
Result language
angličtina
Original language name
Tumor Suppressor miR-34a: Potential Biomarker of TACE Response in HCC
Original language description
PURPOSE: TACE induces variable systemic effects by producing factors that promote inflammation, oncogenesis, and angiogenesis. Here we compare concentrations of microRNAs (miR-21, miR-210 and miR-34a) and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) patients undergoing TACE with degradable (DSM) and nondegradable (DEB) particles and potential use of these biomarker changes for prediction of patient outcomes. MATERIALS AND METHODS: Overall, 52 patients with HCC treated with DSM TACE (24 patients) and DEB TACE (28 patients) were included in this prospective study. Concentrations of studied biomarkers were measured from blood plasma preprocedurally, immediately (< 90 min) postprocedurally, and 24-h after TACE. Levels were compared between DSM and DEB TACE and correlated with treatment response six and 12 months after the first TACE. RESULTS: Both DSM and DEB TACE elevated plasma levels of miR-21, miR-34a, and miR-210 at 24 h post-procedure compared to baseline levels (FC 1.25-4.0). MiR-34a elevation immediately after TACE was significantly associated with nonprogressive disease compared to those with progressive disease at both six months (FC(a): p = 0.014) and 12 months (FC(a): p = 0.029) post-TACE. No significant biomarker changes were found between the embolization particle groups. However, VEGF levels showed a decrease only in the DSM TACE group (FC(24): p = < 0.001). CONCLUSION: Embolization particle type did not significantly impact miRNA or VEGF changes post-TACE. However, miR-34a elevation immediately after the procedure predicts better patient outcome and may prove useful as a biomarkers for the monitoring of clinical outcomes. LEVEL OF EVIDENCE: Level 3 Prospective cohort study.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cardiovascular and interventional radiology
ISSN
0174-1551
e-ISSN
1432-086X
Volume of the periodical
48
Issue of the periodical within the volume
January 2025
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
26-27
UT code for WoS article
001373292200001
EID of the result in the Scopus database
2-s2.0-85211508080