Integration, Cataloguing and Management of Biobanking and Clinical Data Using FAIR Genomes Metadata Schema

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080259" target="_blank" >RIV/00209805:_____/25:00080259 - isvavai.cz</a>
Result on the web
<a href="https://www.sciengine.com/DI/doi/10.3724/2096-7004.di.2025.0005" target="_blank" >https://www.sciengine.com/DI/doi/10.3724/2096-7004.di.2025.0005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3724/2096-7004.di.2025.0005" target="_blank" >10.3724/2096-7004.di.2025.0005</a>

Result language
angličtina
Original language name
Integration, Cataloguing and Management of Biobanking and Clinical Data Using FAIR Genomes Metadata Schema
Original language description
In the dynamic environment of hospitals, valuable real-world data often remain underutilised despite their potential to revolutionize cancer research and personalised medicine. This study explores the challenges and opportunities in managing hospital-generated data, particularly within the Masaryk Memorial Cancer Institute (MMCI) in Brno, Czech Republic. Utilizing Next-Generation Sequencing (NGS) technology, MMCI generates substantial volumes of genomic data. Due to inadequate curation, these data remain difficult to integrate with clinical records for secondary use (such as personalised treatment outcome prediction and patient stratification based on their genomic profiles). This paper proposes solutions based on the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) to enhance data sharing and reuse. The primary output of our work is the development of an automated pipeline that continuously processes and integrates NGS data with clinical and biobank information upon their creation. It stores the data in a special secured repository for sensitive data in a structured form to ensure smooth retrieval.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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