Clindamycin, Ciprofloxacin, and Co-trimoxazole Wound Penetration in Open-Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single-Center Prospective Observational Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080408" target="_blank" >RIV/00209805:_____/25:00080408 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/25:A2603CFH RIV/00843989:_____/25:E0111875 RIV/71009396:_____/25:N0000010

Result on the web

<a href="https://link.springer.com/article/10.1007/s44411-025-00194-6" target="_blank" >https://link.springer.com/article/10.1007/s44411-025-00194-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s44411-025-00194-6" target="_blank" >10.1007/s44411-025-00194-6</a>

Result language

angličtina

Original language name

Clindamycin, Ciprofloxacin, and Co-trimoxazole Wound Penetration in Open-Heart Surgery Patients Receiving Negative Pressure Wound Therapy for Deep Sternal Wound Infection: A Single-Center Prospective Observational Study

Original language description

Background and Objective Achieving sufficient antibiotic concentration in the tissue is a key prerequisite for effective wound infection treatment. We evaluated clindamycin, ciprofloxacin, and co-trimoxazole penetration into exudate among patients treated with negative pressure wound therapy (NPWT). Methods Ten consecutive patients receiving NPWT for deep sternal wound infection (DSWI) after open-heart surgery were enrolled in this prospective observational study. Serum and exudate samples were synchronously collected at 0 (pre-dose), 0.5, 1, 2, 3, and 5 h after clindamycin administration, and at 0, 0.5, 1, 2, 3, and 6 h after ciprofloxacin and co-trimoxazole administration. Wound penetration was assessed as the ratio of the average antibiotic concentration in the wound exudate to that found in serum. Results The wound penetration ratio was significantly higher for free clindamycin concentrations (4.19 +/- 1.43) than for total clindamycin concentrations (0.83 +/- 0.23) (p = 0.007). Wound penetration was similar for both total and free ciprofloxacin concentrations (0.87 +/- 0.35 vs. 0.81 +/- 0.32; p = 0.777). The total and free exudate penetration ratios were about twofold higher for sulfamethoxazole (0.8 and 1.1, respectively) compared to trimethoprim (0.36 and 0.42, respectively). The hospital stay of open-heart surgery patients with DSWI was significantly longer (49 +/- 20 days) than in those without infection (14 +/- 12 days; p &lt; 0.001). No 90-day mortality was observed. One patient experienced late DSWI recurrence. During the median follow-up of 2.3 years, all-cause mortality was 4.8%. Conclusion Clindamycin, ciprofloxacin, and co-trimoxazole effectively penetrated wound exudate in patients on NPWT for post-sternotomy DSWI.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30212 - Surgery

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislavské lekárske listy

ISSN

0006-9248

e-ISSN

1336-0345

Volume of the periodical

126

Issue of the periodical within the volume

8

Country of publishing house

SK - SLOVAKIA

Number of pages

13

Pages from-to

1891-1903

UT code for WoS article

001495243100001

EID of the result in the Scopus database

2-s2.0-105006613076