Association between neoadjuvant paclitaxel dose intensity and outcomes in early triple-negative and HER2-positive breast cancer: a real-world data analysis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080659" target="_blank" >RIV/00209805:_____/25:00080659 - isvavai.cz</a>

Result on the web

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12836558/pdf/main.pdf" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC12836558/pdf/main.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.esmorw.2025.100158" target="_blank" >10.1016/j.esmorw.2025.100158</a>

Result language

angličtina

Original language name

Association between neoadjuvant paclitaxel dose intensity and outcomes in early triple-negative and HER2-positive breast cancer: a real-world data analysis

Original language description

Background: Reduction of paclitaxel dose intensity (PDI) is frequent during neoadjuvant treatment of high-risk early triple-negative (TN) and human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC), due toxicity. The association between PDI and cancer outcomes is uncertain.&lt;br /&gt; Patients and methods: We collected across eight European cancer centers (DigiCore consortium) a cohort of early TN and HER2-positive BC patients who received neoadjuvant anthracyclines and weekly paclitaxel. For each subtype, we assessed whether a threshold of reduced PDI (through dose reduction, treatment delay or early cessation) was associated with reduced pathological complete response (pCR) rate. We then described the association between reduced PDI, invasive BC-free survival (IBCFS), and overall survival.&lt;br /&gt; Results: We included 514 TNBC and 249 HER2-positive BC patients. PDI reductions were required in 82.9% and 63.9% patients, respectively. The optimal cut-off separating high and low PDI was 69% and 72%, respectively. Low PDI was TNBC (29.8% of patients), but not in HER2-positive BC (22.1% of patients), significantly associated with a reduced pCR rate, compared with high PDI (37.3% versus 55.1%) (odds ratio 0.48, 95% confidence interval 0.33-0.71, P &lt; 0.001). TNBC, the estimated IBCFS at 36 months was 77.9% in the PDI-low and 89.2% in the PDI-high group (hazard ratio 2.19, 95% confidence interval 1.29-3.73, P = 0.004).&lt;br /&gt; Conclusions: Reduction of PDI is frequently required during neoadjuvant treatment in early TNBC and HER2-positive BC, and is associated with lower pCR rate and IBCFS in TNBC. Reduction of PDI needs careful consideration, balancing adverse events and potential impact. Confirmation in independent datasets is warranted.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ESMO real world data and digital oncology

ISSN

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e-ISSN

2949-8201

Volume of the periodical

9

Issue of the periodical within the volume

September 2025

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

100158

UT code for WoS article

001634035400004

EID of the result in the Scopus database

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