Assessment of estrogen and progesterone receptors and their combined phenotypes in 287 breast carcinomas

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F99%3A00000053" target="_blank" >RIV/00209805:_____/99:00000053 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Assessment of estrogen and progesterone receptors and their combined phenotypes in 287 breast carcinomas
Original language description
Using Spearman rank correlation, ER by both methods correlated significantly (p<0,0001), PR weakly (p=0,04). Using thresholds (IHC 10%, LSA: ER 10, PR 15 fmol/mg), concordance was 64% for ER and 53% for PR. As to combined phenotypes, ER + PR+ IHC found ER + PR+ and ER- PR- in 89% tumors, LSA in 66%, ER+ PR- in 10% and 6%, ER- PR+ under 1% and in 28%, respectively. Conclusions: IHC and LSA are comparable for ER, not for PR detection. IHC greatly reduces frequency of imaginary phenotype ER-PR+, thus reflects the ER function better than LSA. IHC appears as method of choice for routine. Nevertheless, LSA can be still useful for research since free receptor fractions may be important in specific biological pathways, e.g. apoptosis.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
1999
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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